An exophytic mass on the mandible of an immunocompromised man.

Diagnosis: Coexistent Cryptococcus neoformans and Kaposi sarcoma in a patient with AIDS. Histopathologic examination revealed multiple budding yeast forms surrounded bya clear halo (Figure 1A). Grocott-methaminesilver and mucicarmine (Figure 1B) stains highlighted these organisms and their capsules, respectively. A proliferation of atypical spindle cells arranged in fascicles, associated with slit-like vascular spaces and extravasated red blood cells, was also identified (Figure 1A). Immunohistochemistry for human herpesvirus 8 demonstrated positive nuclear staining within these spindled cells (Figure 2). These findings were diagnostic for cutaneous Cryptococcus infection in the context of Kaposi sarcoma (KS). The patient was treated with amphotericin B and flucytosine followed by fluconazole for his cryptococcal infection; emtricitabine, tenofovir, and raltegravir were initiated as therapy for AIDS. Doxorubicin therapy was initiated for probable multifocal KS. The patient’s cutaneous lesions have improved on this regimen, with concomitant resolution of his lower extremity swelling and improvement in breath sounds. His human immunodeficiency virus (HIV) load is currently undetectable. Cutaneous disorders are estimated to affect approximately 64% of patients with HIV, with an increasing prevalence at lower CD4 counts [1]. These conditions include common infections and malignancies such as Staphylococcus aureus and squamous cell carcinoma, as well as a variety of inflammatory dermatoses that are often more severe than in immunocompetent patients [1]. Of particular concern are those opportunistic infections and neoplasms that are classified as AIDS-defining illnesses, including cryptococcosis and KS. Often these conditions have a protean presentation and may simulate one another [2, 3]. Nevertheless, the coexistence of Cryptococcus and KS in a single clinical lesion is an uncommon occurrence [4–8]. Colocalization of these infections may be the presenting sign of AIDS in patients with known HIV or those who had been previously undiagnosed; it has also been associated with paradoxical immune reconstitution inflammatory syndrome (IRIS) following initiation of highly active antiretroviral therapy (HAART) [5, 8]. The latter association is particularly noteworthy as significant morbidity and mortality are associated with KS-IRIS, particularly among patients with visceral KS [9].